The concept of transformation is growing in relevance because of the complex nature of the challenges we face. Overcoming serious challenges, such as climate change, hunger, obesity, mental health, and inequalities, cannot be achieved by just improving what we already do. Instead, we need much deeper and more fundamental kinds of change to transcend the systems, thinking, and mindsets that have led to, and perpetuate, the challenges. This report is an introductory guide that explains how transformation is different to other kinds of change and some of the approaches that can support it. The guide, produced by two experts in the field of transformational practice, is for scholars and practitioners seeking to instigate an initiative, approach or campaign which is intended to be transformational.